Abstract

Review Article

Parabens: The love - hate molecule

PD Gupta* and K Pushkala

Published: 02 May, 2020 | Volume 3 - Issue 1 | Pages: 037-038

Parabens are the esters of para-hydroxybenzoic acid [1], mimicking oestrogen, the hormone which makes a woman a woman; women love it and men hate it. 

Read Full Article HTML DOI: 10.29328/journal.cjog.1001047 Cite this Article Read Full Article PDF

References

  1. Freese E, Sheu CW, Galliers E. Function of lipophilic acids as antimicrobial food additives. Nature. 1973; 241: 321–325. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/4633553
  2. Błędzka lD, Gromadzińska J,  Wąsowicz W. Parabens. From environmental studies to human health. Environ Internl. 2014; 67: 27-42. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24657492  
  3. Chen J, Ahn KC, Gee NA, Gee SJ, Hammock BD, et al. Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products. Toxicol Applied pharmacol. 2007; 221; 278–284. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/17481686
  4. Karwacka A, Zamkowska D, Radwan M, Jurewicz J. Exposure to modern, widespread environmental endocrine disrupting chemicals and their effect on the reproductive potential of women: an overview of current epidemiological evidence. Hum Fertil (Camb). 2019; 31:1-25. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/28758506
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  8. Smarr MM, Sundaram R, Honda M, Kannan K, Buck Louis GM. Urinary concentrations of parabens and other antimicrobial chemicals and their association with couples’ fecundity. Environ Health Perspect. 2016; 124: 730–736. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27286252
  9. Manservisi F, Gopalakrishnan K, Tibaldi E, Hysi A, Iezzi M, et al. Effect of maternal exposure to endocrine disrupting chemicals on reproduction and mammary gland development in female Sprague-Dawley rats. Reproductive Toxicology. 2015; 54: 110-119. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25554385
  10. Guerra MT, Sanabria M, Leite GA, Borges CS, Cucielo MS, et al. Maternal exposure to butyl paraben impairs testicular structure and sperm quality on male rats. Environ Toxicol. 2017; 32:1273-1289. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27444704
  11. Oishi S. Effects of butylparaben on the male reproductive system in rats. Toxicol Ind Health. 2001; 17: 31-39. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/12004923
  12. Ali EH, Elgoly AH. Combined prenatal and postnatal butylparaben exposure produces autism-like symptoms in offspring: comparison with valproic acid autistic model. Pharmacol Biochem Behav. 2013; 111: 102-110. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24036472
  13. Kawaguchi M, Irie K, Morohoshi K, Watanabe G, Taya K, et al. Maternal isobutyl-paraben exposure alters anxiety and passive avoidance test performance in adult male rats. Neurosci Res. 2009; 65: 136-140. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/19560493
  14. Gupta PD, Pushkala K. Increasing woman's health concern due to xenoestrogens and parabens: a review. J Cell Tissue Res. 2019; 19 6829-6832.

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