Abstract

Research Article

COVID-19 in pregnancy: Our experience at a tertiary maternity unit in France

Darido Jessie*, El Haddad Cynthia, Diari Jed, Grevoul Fesquet Julie, Bouzid Nassima, Bobric Andrea, Lakhdara Nefissa, Bazzi Zeinab, Lebis Cindy, Khadam Louay and Rigonnot Luc

Published: 24 June, 2020 | Volume 3 - Issue 1 | Pages: 054-064

Objectives: Our main objectives are to reveal the pregnancy and neonatal impacts of COVID-19 infection and to compare it to the results that are reported in the literature.

Methods and materials: The characteristics of the admitted pregnant patients COVID-19 positive with their initial presentation, course at the hospital, and short term follow-up are exposed. Correlation of the age and gestational age with the severity of the disease was calculated.

Results: Thirty five COVID-19 positive pregnant patients presented between the beginning of March and the end of April 2020. From 5 weeks till 41 weeks of gestation, all trimesters were included. The mean of age is 32 and the BMI equal 28.2. Associated comorbidities included not only diabetes and hypertension but also PCOS. The symptomatology was considered mild in most of the cases. The distribution of the symptoms included cough in 86%. 10 out of 35 delivered and cesarean was performed in 50% of the cases. The mean length of stay is 6 days. Neither maternal nor neonatal deaths occurred. There is a significant correlation between the age of the patient and the severity of the disease but this is not the case with gestational age.

Conclusion: Our results were comparable to the literature in terms of initial presentation, associated comorbidities and the length of stay. Despite the fact that the cesarean rate was high, it was far below that of the literature. More data is still needed about COVID-19 in pregnancy.

Read Full Article HTML DOI: 10.29328/journal.cjog.1001051 Cite this Article Read Full Article PDF

Keywords:

COVID-19; SARS-COV-2; Coronavirus; Infection; Pregnancy; Masks; Maternal complications; Obstetric complications; Review; Fetus; Intrauterine transmission; Route of delivery; Comorbidities

References

  1. Li X, Geng M, Peng Y, Meng L, Lu S. Molecular immune pathogenesis and diagnosis of COVID-19. J Pharmaceut Analysis. 2020; 10: 102-108. PubMed: https://pubmed.ncbi.nlm.nih.gov/32282863
  2. Wang W, Xu Y, Gao R, Lu R, Han K, et al. Detection of SARS-COV-2 in different types of clinical specimens. JAMA. 323: 1843-1844. PubMed: https://pubmed.ncbi.nlm.nih.gov/32159775/
  3. Rasmusen S, Smulian J, Lednicky J, Wen T, Jamieson D. Coronavirus disease 2019 and pregnancy: what obstetricians need to know. AJOG. 2020; 222: 415-426. PubMed: https://pubmed.ncbi.nlm.nih.gov/32105680/
  4. Dashraat P, Wong JLJ, Lim MXK, Lim LM, Li S, et al. Coronavirus disease 2019 (COVID 19) pandemic and pregnancy. Am J obstet Gynecol. 2020; 222: 521-531. PubMed: https://pubmed.ncbi.nlm.nih.gov/32217113/
  5. Deslandes A, Berti V, Tandjaoui-Lambotte Y, Alloui C, Carbonnelle E, et al. SARS-COV2 was already spreading in France in late December 2019. Int J Antimicrob Agents. 2020; 55: 106006. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196402/
  6. Masmejan S, Pomar L, Lepigeon K, Favre G, Baud D, et al. COVID-19 et grossesse [COVID-19 and pregnancy]. Rev Med Suisse. 2020; 16: 944-946.
  7. Di Mascio D, Khalil A, Saccone G, Rizzo G, Buca D, et al. Outcome of coronavirus spectrum infections (SARS, MERS COVID 1-19) during pregnancy a systematic review and meta-analysis. Am J obstet Gynecol MFM. 2020; 100-107. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104131/
  8. Monteleone PA, Nakano M, Lazar V, Gomes AP, de H Martin, et al. A review of initial data on pregnancy during the COVID-19 outbreak: implications for assisted reproductive treatments JBRA Assist Reprod. 2020; 24: 219-225. PubMed: https://pubmed.ncbi.nlm.nih.gov/32354663
  9. Lui H, Wang LL, Zhao SJ, Kwak-Kim J Mor G, Liao AH. why are pregnant woman susceptible to COVID-19? An immunological view point J Reprod Immunol. 2020; 139: 103122. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156163/
  10. CDC COVID-19 response team preliminary estimates of the prevalence of selected underlying health conditions among patients with coronavirus disease 2019-united states. 2020. MMWR Morb Mortal Wkly Rep. 2020; 69: 382-386.
  11. Zaigham M, Andersson O. Maternal and perinatal outcoms with COVID-19: A systematic review of 108 pregnancies Acta obstet Gynecol Sci. 2020.
  12. Panahi L, Amiri M, Pouy S. Risks of Novel coronavirus in pregnancy; a narrative review. Arch Acad Emerg Med. 2020; 8: e34. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092922/
  13. Yan J, Guo J, Fan C, Juan J, Yu XX, et al. Coronavirus disease 2019 (COVID-19) in pregnant women: A report based on 116 cases Am J obstet Gynecol. 2020; 111. e1–111.e14. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177142/
  14. Wu Z, McGoogan JM. Characteristics of and important Lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese center for disease control and prevention. JAMA. 2020. PubMed: https://pubmed.ncbi.nlm.nih.gov/32091533/
  15. Liu D, Li L, wu X, et al. Pregnancy and perinatal outcomes of women with coronavirus disease (COVID-19) pneumonia: A preliminary Analysis. AJR Am J Roentgenol. 2020; 1-6.
  16. Blitz MJ, Grunebaum A, Tekbali A. Intensive care unit admissions for pregnant and non-pregnant women with COVID-19. Am J obstet Gynecol. 2020.
  17. Zhao X, Jiang Y, Zhao Y. Analysis of the susceptibility to COVID -19 in pregnancy and recommendations on potential drug screening Eur J clin Microbiol infect Dis. 2020; 1-12.
  18. Pierce-Williams RAM, Burd J, Felder L, houry R, Bernstein PS, et al. Clinical course of severe and critical COVID-19 in hospitalized pregnancies: a US cohort study. Am J obstet Gynecol MFM. 2020; 100134. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/32391519
  19. Yang Z, Wang M, Zhu Z, Liu Y. Coronavirus disease 2019 (COVIS-19) and pregnancy: a systematic review. J Matern Fetal Neonatal Med. 2020; 1-4. PubMed: https://pubmed.ncbi.nlm.nih.gov/32354293/
  20. Kasraeian M, Zare M, Vafaei H, et al COVID 19 pneumonia and oregnancy ; a systematic review and meta analysis. J matern Fetal neonatal Med. 2020; 1-8. PubMed:
  21. Juan J, Gil MM, Rong Z, Zhang Y, Yang H, et al. Effects of coronavirus disease 2019 (Covid-19) on maternal, perinatal and neonatal outcomes: a systematic review. Ultrasound Obstet Gynecol. 2020.
  22. Zhang L, Jiang Y, Mei M, Cheng BH, Zhou XCN et al. [Analysis of the Pregnancy Outcomes in Pregnant Women With COVID-19 in Hubei Province]. Zhongua Fu Chan Ke Za Zhi. 2020; 55: 166-171. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/32145714
  23. Alzamora MC, Paredes T, Caceres D, Webb CM, valdez LM, et al. Severe COVID 19 during pregnancy and possible vertical transmission. Am J Perinatal. 2020. PubMed: https://pubmed.ncbi.nlm.nih.gov/32305046/
  24. Chen H, GuoJ, Wang C, Luo F, Yu X, et al. Clinical characteristics an intrauterine vertical transmission potential of COVID19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020; 395: 809-815. PubMed: https://pubmed.ncbi.nlm.nih.gov/32151335/
  25. Chen S, Huang B, Luo DJ, Li X, Yang F, et al. [Pregnancy With New Coronavirus Infection: Clinical Characteristics and Placental Pathological Analysis of Three Cases]. Zhonghua Bing Li Xue Za Zhi. 2020; 49: 418-423. PubMed: https://pubmed.ncbi.nlm.nih.gov/32114744/
  26. Chen D, Yamg H, Cao Y, Cheng W, Duan T, et al. Expert consensus for managing pregnant women and neonates born to mothers with suspected or confirmed novel coronavirus (COVID 19) infection. Int J Gynaecol obstet. 2020; 149: 130-136. PubMed: https://pubmed.ncbi.nlm.nih.gov/32196655/
  27. Elshafgeey F, Magdi R, Hindi N, Elshebiny M, Farrag N, et al. A systematic scoping review of COVID 19 during pregnancy and childbirth. Int J Gynaecol Obstet. 2020; 150: 47-52. PubMed: https://pubmed.ncbi.nlm.nih.gov/32330287/

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