Research Article

Gestational hypercholesterolemia helps detect familial hypercholesterolemia and prevent late pregnancy complications

Josef Hyánek*, František Pehal, Kseniya Dryahina, Ladislava Dubská, Blanka Míková, Lada Gombíková, Miroslav Průcha, Stanislav Kubů, Petra Haláčková and Jaroslav Feyreisl

Published: 02 July, 2019 | Volume 2 - Issue 2 | Pages: 079-089

Introduction: In this retrospective study, we comment on the cause and diagnostic potential of the elevated serum total cholesterol and some non-cholesterol sterols in a population of healthy pregnant women from Prague, Czech Republic.

Methods: Based on a total of 21,000 clinical biochemistry tests of healthy pregnant women with hypercholesterolemia observed during pregnancy, a testing group of 84 women with a total cholesterol (TC) above 7.0 mmol/l was established to analyze their non-cholesterol sterols (NCS) by Gas Chromatography–Mass Spectrometry. Lathosterol (Lat) and desmosterol (Des) were evaluated as markers of endogenous cholesterol synthesis, whereas campesterol (Cam) and sitosterol (Sit) were analysed as markers of intestinal absorption.

Results: In the basic population, the frequency of gestational hypercholesterolemia with the serum TC levels > 7.0mmol/l was 1 to 136.The mean values were: TC 6.8 mmol/l, LDL-C 4.6 mmol/l, and HDL-C 2.2 mmol/l. In the selected testing group of 84, the mean values were: Lat 7.8+/-1.7 μmol/l, Des 4.7+/-0.9 μmol/l, Cam 9.8+/-2.6 μmol/l, and Sit 9.6+/-3.8 μmol/l. Lat correlated with TC (r = 0.53), LDL-C (r = 0.36), and non-HDL-C (r = 0.35). No such correlations were observed for Cam or Sit.

Conclusion: Our findings prove that gestational hypercholesterolemia is caused by increased endogenous cholesterol synthesis via lathosterol. Subsequently, we demonstrate how a single cholesterol test taken in the fifth to sixth month gestation can efficiently help detect familial hypercholesterolemia, and prevent related late pregnancy circulatory complications.

Read Full Article HTML DOI: 10.29328/journal.cjog.1001026 Cite this Article Read Full Article PDF


Hypercholesterolemia during pregnancy; Gestational hypercholesterolemia; Familial hypercholesterolemia; Non-cholesterol sterols; Lathosterol; Desmosterol; Campesterol; Sitosterol


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  • Gestational hypercholesterolemia helps detect familial hypercholesterolemia and prevent late pregnancy complications
    Josef Hyánek*, František Pehal, Kseniya Dryahina, Ladislava Dubská, Blanka Míková, Lada Gombíková, Miroslav Průcha, Stanislav Kubů, Petra Haláčková and Jaroslav Feyreisl Josef Hyánek*,František Pehal,Kseniya Dryahina,Ladislava Dubská,Blanka Míková,Lada Gombíková,Miroslav Průcha,Stanislav Kubů,Petra Haláčková,Jaroslav Feyreisl. Gestational hypercholesterolemia helps detect familial hypercholesterolemia and prevent late pregnancy complications. . 2019 doi: 10.29328/journal.cjog.1001026; 2: 079-089

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