Abstract

Case Report

A rare case of giant ovarian serous cystadenoma presenting as psuedo-meigs syndrome

Richmond Ronald Gomes*, Sayeda Noureen and Habiba Akhter

Published: 18 January, 2021 | Volume 4 - Issue 1 | Pages: 010-014

Meigs’ syndrome is a rare condition characterized by the presence of a benign fibroma of the ovary, ascites and pleural effusion. Other benign cysts of the ovary (such as struma ovarii, mucinous cystadenoma, serous cystadenoma and teratomas), leiomyoma of the uterus, and secondary metastatic tumours to ovary if associated with hydro thorax and ascites are referred to as ‘Pseudo-Meigs” syndrome. It very uncommon and diagnosis is made difficult by symptoms that usually mimic disseminated malignancy or tuberculosis. The gold standard treatment is laparotomy and, by definition of the syndrome, after tumor removal, the symptoms resolves and the patients become asymptomatic. We presented an 18 years old girl with giant ovarian serous cystadenoma with associated pseudo-meigs syndrome, successfully managed in a low resources setting.

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Keywords:

Meigs; Pseudo-meigs; Serous cystadenoma; Hydrothorax; Ascites

References

  1. Lurie S. Meigs' syndrome: the history of the eponym. Eur J Obstet Gynecol Reprod Biol. 2000; 92: 199–204. PubMed: https://pubmed.ncbi.nlm.nih.gov/10996681/
  2. Lallemand A. Contribution a'l'étude des fibromes de l'ovaire. Thése pourle doctorat en médecine. Paris. 1896; 285.
  3. Meigh JV, Cass JW. Fibroma of the ovary with ascites and hydrothorax: With a report of seven cases. Am J Obstet Gynecol. 1937; 33: 249–267.
  4. Rhoads JE, Terrell AW. Ovarian fibroma with ascites and hydrothorax (Meigs syndrome): a case. JAMA. 1937; 109: 1684.
  5. Meigs JV. Fibroma of the ovary with ascites and hydrothorax‐ Meigs syndrome. Am J Obstet Gynecol. 1954; 67: 962–985. PubMed: https://pubmed.ncbi.nlm.nih.gov/13148256/
  6. Peparini N, Chirletti P. Ovarian malignancies with cytologically negative pleural and peritoneal effusions: demons' or meigs' pseudo‐syndromes? Int J Surg Pathol. 2009; 17: 396–397. PubMed: https://pubmed.ncbi.nlm.nih.gov/19448068/
  7. Martin F, Brouche S, Haidar A. A propos d'un cas avec tumeur ovarienne de la granulosa. Rev Pneumol Clin. 1990; 46: 123–124.
  8. Shih JA, Garrett LA, Carbo AR. Meigs' syndrome: a sheep in Wolf's clothing. Am J Med. 2019; 132: 803-804. PubMed: https://pubmed.ncbi.nlm.nih.gov/31153867/
  9. Brun JL. Demons syndrome revisited: a review of the literature. Gynecol Oncol. 2007; 105: 796-800. PubMed: https://pubmed.ncbi.nlm.nih.gov/17433421/
  10. Human Reproduction. University of Utah Medpath. http://library.med.utah.edu/kw/human_reprod/seminars/seminar4B2.html
  11. Cheng EJ, Kurman RJ, Wang M, Oldt R, Wang BG, et al. "Molecular genetic analysis of ovarian serous cystadenomas". Lab Invest. 2004; 84: 778–784. PubMed: https://pubmed.ncbi.nlm.nih.gov/15077125/
  12. Bhatla N. Jeffcoate’s Principles of Gynecology. International edn. Revised, and updated from the 5th edn. Arnold publishers, London. 2001: 523-4.
  13. Hernandez E, Atkinson B. Clinical Gynecologic Pathology Philadelphia. W.B. Saunders Company. 1996; 521.
  14. Ishiko O, Yoshida H, Sumi T, Hirai K, Ogita S. Vascular endothelial growth factor levels in pleural and peritoneal fluid in Meigs' syndrome. Eur J Obstet Gynecol Reprod Biol. 2001; 98: 129-130. PubMed: https://pubmed.ncbi.nlm.nih.gov/11516814/
  15. Krenke R, Maskey-Warzechowska M, Korczynski P, Zielinska- Krawczyk M, Klimiuk J, et al. Pleural effusion in Meigs’ Syndrome-transudate Or Exudate?: Systematic review of the literature. Medicine (Baltimore). 2015; 94: e2114. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008483/
  16. Handler CE, Fray RE, Snashall PD. Atypical Meigs’ syndrome. Thorax. 1982; 37: 396–397. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC459328/
  17. Timmerman D, Moerman P, Vergote I. Meigs' syndrome with elevated serum CA 125 levels: two case reports and review of the literature. Gynecol Oncol. 1995; 59: 405-408. PubMed: https://pubmed.ncbi.nlm.nih.gov/8522265/
  18. Benjapibal M, Sangkarat S, Laiwejpithaya S, Viriyapak B, Chaopotong P, et al. Meigs' syndrome with elevated serum CA125: case report and review of the literature. Case Rep Oncol. 2009, 2: 61-66. PubMed: https://pubmed.ncbi.nlm.nih.gov/20740147/
  19. Lin JY, Angel C, Sickel JZ. Meigs syndrome with elevated serum CA 125. Obstet Gynecol. 1992; 80: 563-566. PubMed: https://pubmed.ncbi.nlm.nih.gov/1495739/
  20. Liou JH, Su TC, Hsu JC. Meigs' syndrome with elevated serum cancer antigen 125 levels in a case of ovarian sclerosing stromal tumor. Taiwan J Obstet Gynecol. 2011; 50: 196-200. PubMed: https://pubmed.ncbi.nlm.nih.gov/21791307/
  21. Ehdaivand S. "Ovary tumor - serous tumors - Serous cystadenoma / adenofibroma / surface papilloma". Pathology Outlines. Topic Completed: 1 June 2012. 2020.
  22. Yadav S, Tomar R, Verma N, Khurana N, Triathi R. Struma ovarii with pseudo-Meigs' syndrome and raised cancer antigen-125 levels masquerading as an ovarian carcinoma: case report and literature review. Sultan Qaboos Univ Med J. 2017; 17: e229-e233. PubMed: https://pubmed.ncbi.nlm.nih.gov/28690899/
  23. Santangelo M, Battaglia M, Vescio G, Sammarco G, Gallelli G, et al. Meigs´ syndrome: its clinical picture and treatment. Ann Ital Chir. 2000; 71: 115-119. PubMed: https://pubmed.ncbi.nlm.nih.gov/10829533/
  24. Rozier R, Berger A, Cugnenc PH. Meigs´ syndrome: is it possible to make a preoperative diagnosis? J Gynecol Obstet Biol Reprod. 1998; 27: 517-522. PubMed: https://pubmed.ncbi.nlm.nih.gov/9791579/
  25. Dunn JS, Jr, Anderson CD, Method MW, Brost BC. Hydropic degenerating leiomyoma presenting as pseudo-Meigs syndrome with elevated CA 125. Obstet Gynecol. 1998, 92: 648-649.

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