Experiment of a novel four-spherical intrauterine contraceptive device with nickel-titanium

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Submitted: October 8, 2020
Published: Oct 20, 2020
DOI: 10.29328/journal.cjog.1001068
Keywords:
Four-spherical intrauterine device (4-SIUD), Contraception, Rhesus macaques
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Jian-Chun Yu
Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Key Laboratory for Improving Birth Outcome Technique, Maternal and Child Health Care Hospital of Shandong Province, 238 East Road of Jingshi, Jinan, Shandong 250014, People’s Republic of China
Mei-Hua Zhang
Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Key Laboratory for Improving Birth Outcome Technique, Maternal and Child Health Care Hospital of Shandong Province, 238 East Road of Jingshi, Jinan, Shandong 250014, People’s Republic of China
Ling Yu
Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Key Laboratory for Improving Birth Outcome Technique, Maternal and Child Health Care Hospital of Shandong Province, 238 East Road of Jingshi, Jinan, Shandong 250014, People’s Republic of China
Li-Ping Zhai
Shandong Provincial Institute of Control of Endemic Disease, East Road of Jingshi, Jinan, Shandong 250014, People’s Republic of China
Xia Song
Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Key Laboratory for Improving Birth Outcome Technique, Maternal and Child Health Care Hospital of Shandong Province, 238 East Road of Jingshi, Jinan, Shandong 250014, People’s Republic of China
Fang-Di Dong
Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Key Laboratory for Improving Birth Outcome Technique, Maternal and Child Health Care Hospital of Shandong Province, 238 East Road of Jingshi, Jinan, Shandong 250014, People’s Republic of China
Yi Qiu
Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Key Laboratory for Improving Birth Outcome Technique, Maternal and Child Health Care Hospital of Shandong Province, 238 East Road of Jingshi, Jinan, Shandong 250014, People’s Republic of China

Abstract

The aim of this study was to develop a novel four-spherical intrauterine contraceptive device (4-SIUD) with nickel-titanium (Ni-Ti) for human, and to evaluate the contraceptive effect. The 4-SIUD composed of 4 mesh spheres and 5 support arms. The shape of 4-SIUD was like a “T”. The height (H), upper width (D) and thickness of the 4-SIUD for macaques were 0.8 cm, 0.5 cm and 0.3 cm, and for human were 4.5 cm, 4.0 cm and 0.8 cm, respectively. The 4-SIUD was inserted into 5 macaques and pregnancy was not observed at 12 months. Three women used the 4-SIUD for 12 months, uterine perforations, expulsion, pain, and pelvic inflammatory did not occur. The results suggested that the 4-SIUD is appropriate for rhesus macaques and human use, and has a good contraceptive effect.

Article Details

Yu, J.-C., Zhang, M.-H., Yu, L., Zhai, L.-P., Song, X., Dong, F.-D., & Qiu, Y. (2020). Experiment of a novel four-spherical intrauterine contraceptive device with nickel-titanium. Clinical Journal of Obstetrics and Gynecology, 3(2), 142–144. https://doi.org/10.29328/journal.cjog.1001068
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Copyright (c) 2020 Yu JC, et al.

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Jian-Chun Yu, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Key Laboratory for Improving Birth Outcome Technique, Maternal and Child Health Care Hospital of Shandong Province, 238 East Road of Jingshi, Jinan, Shandong 250014, People’s Republic of China

   

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