Abstract

Case Presentation

Apert Syndrome: A Case Report

Renardy Reza Razali and Munawar Adhar Lubis*

Published: 27 December, 2023 | Volume 6 - Issue 4 | Pages: 233-235

Background: Apert syndrome is a type 1 acrocephalosyndactyly, a rare syndrome characterized by the presence of multiple craniosynostoses, dysmorphic facial manifestations, and syndactyly of hand and feet. It affects 1:100.00 of birth and is the second most common of syndromic craniosynostosis. Molecular genetic tests that identify the heterozygous pathogenic variant in FGFR2 genes - identical with Apert syndrome cost too high to be applicable in developing countries. Therefore, the diagnosis of Apert syndrome should be suspected from the clinical findings. Three cases from the Community of Indonesian Apert Warrior Group were collected. These series were based on medical and surgical records. We obtained the patient characteristics from the phenotypic manifestations only. 
Case report: We present a case of a newborn baby girl, with similar anatomical findings, such as skull shape abnormality, midface hypoplasia, intraoral disfigurement, and hands and feet deformities that resemble Apert Syndrome. Our series presents similar Apert syndrome characteristics, such as typical craniofacial dysmorphic with symmetrical syndactyly of both upper and lower extremities. These clinical findings are essential to establish an initial diagnosis of Apert Syndrome.

Read Full Article HTML DOI: 10.29328/journal.cjog.1001154 Cite this Article Read Full Article PDF

Keywords:

Apert syndrome; Craniosynostosis; Syndactyly

References

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  • Apert Syndrome: A Case Report
    Renardy Reza Razali and Munawar Adhar Lubis* Renardy Reza Razali,Munawar Adhar Lubis*. Apert Syndrome: A Case Report. . 2023 doi: 10.29328/journal.cjog.1001154; 6: 233-235

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